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Antigenic Specificity | Tyk2 |
Clone | polyclonal |
Host Species | Mouse |
Reactive Species | human |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Tyk2 (tyrosine kinase 2), with 1187-amino acid protein (about 131kDa), belongs to the family of non-receptor janus tyrosine kinases, which also includes Jak1, Jak2, and Jak3. Kinases of the Jak family regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Tyk2 is activated by a variety of cytokines. IFN-alpha, IFN-beta, IL-6, IL-10, IL-12, and IL-13 and promotes IFN-gamma production by Th1-type CD4 cells. Tyk2 can be viewed as a dual-function Jak, mediating both pro-inflammatory and anti-inflammatory cytokine responses. Tyk2 is also an important regulator of lymphoid tumor surveillance. |
Immunogen | Immunogen: Purified recombinant fragment of Tyk2 expressed in E. Coli. |
Other Names | [JTK1], [TYK2; TYK2; JTK1; IMD35] |
Gene, Accession # | [Tyk2], Gene ID: 7297, NCBI: NP_003322.3, UniProt: P29597 |
Catalog # | MBS850296 |
Price | $280 |
Order / More Info | Tyk2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |