Endoglin, Human Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | Endoglin, Human |
| Clone | E9 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | F, Flow Cytometry (FC/FACS), Immunoassay (IA), Immunoprecipitation (IP), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Product Description: The monoclonal antibody E9 reacts with Endoglin, a 190 kDa homodimeric transmembrane glycoprotein composed of disulfide-linked subunits. The external domain binds TGF-beta1 and -beta3 isoforms with high affinity. Two different isoforms (L and S) of CD105 with capacity to bind TGF-beta have been characterized, which differ in the amino acid composition of their cytoplasmic tails. Mutations in the gene encoding endoglin have been linked to the human disease hereditary hemorrhagic telangiectasia type 1 (HHT1), a vascular disorder characterized by localized vascular dysplasia and a tendency towards arteriovenous malformations. Mice expressing a single CD105 allele develop external signs of disease similar to human HHT1, sup |
| Immunogen | n/a |
| Other Names | [endoglin isoform 1; Endoglin; endoglin; CD105 antigen; endoglin; CD_antigen: CD105], [ENG; ENG; END; HHT1; ORW1; END] |
| Gene, Accession # | Gene ID: 2022, NCBI: NP_001108225.1 |
| Catalog # | MBS584357 |
| Price | $520 |
| Order / More Info | Endoglin, Human Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Wang, J et al; Breast carcinoma: comparative study if tumor vasculate using two endothelial cell markers. J Natl Cancer Inst 1994, 86: 386 2. Pichuantes, S et al; Mapping epitopes to distinct regions of the extracellular domain of endoglin using bacterially expressed recombinant fragments. Tissue Antigens 1997, 50: 265 3. Kumar, S et al; Breast carcinoma: vascular density determined using CD105 antibody correlates with tumor prognosis. Cancer Research 1999, 59: 856 4. Li, C et al; Plasma levels of soluble CD105 correlates with metastasis in patients with breast cancer. Int J Cancer 2000, 89: 122 5. Li, C et al; Both high intratumoral microvessel density determined using CD105 antibody and elevated plasma levels of CD105 in colorectal cancer patients correlate with poor prognosis. B J Cancer 2003, 88: 1424 6. Costello, B et al; Perfusion of 99Tcm-labeled CD105 Mab into kidneys from patients with renal carcinoma suggests that CD105 is a promising vascular target. Int J Cancer 2004, 109: 436 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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