XRCC6 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | XRCC6 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Ku is a heterodimeric protein composed of two subunits (Ku70 and Ku80) originally identified by researchers as autoantigens associated with several autoimmune diseases including scleroderma, polymyositis, and systemic lupus erythematosus (1). Ku is an abundant, ubiquitously expressed nuclear protein that binds to and stabilizes the ends of DNA at telomeres or double-stranded DNA breaks (2-5). The Ku70/Ku80 heterodimer has ATP-dependent DNA helicase activity and functions as the DNA-binding regulatory component of DNA-dependent protein kinase (DNA-PK) (6-8). The assembly of the DNA-PK complex at DNA ends is required for nonhomologous end-joining (NHEJ), one mechanism involved in double-stranded DNA break repair and V(D)J recombination (8). D |
| Immunogen | Immunogen: Recombinant protein of human XRCC6 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [CTC75; CTCBF; G22P1; KU70; ML8; TLAA] |
| Gene, Accession # | [XRCC6], Gene ID: 2547, NCBI: NP_001275905.1, UniProt: P12956 |
| Catalog # | MBS8503272 |
| Price | $310 |
| Order / More Info | XRCC6 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Tuteja, R. and Tuteja, N. (2000) Crit. Rev. Biochem. Mol. Biol. 35, 1-33. 2. Blier, P.R. et al. (1993) J. Biol. Chem. 268, 7594-7601. 3. Jin, S. and Weaver, D.T. (1997) EMBO J. 16, 6874-6885. 4. Boulton, S.J. and Jackson, S.P. (1998) EMBO J. 17, 1819-1828. 5. Gravel, S. et al. (1998) Science 280, 741-744. 6. Cao, Q.P. et al. (1994) Biochemistry 33, 8548-8557. 7. Lees-Miller, S.P. et al. (1990) Mol. Cell Biol. 10, 6472-6481. 8. Collis, S.J. et al. (2005) Oncogene 24, 949-961. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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