IRE1p Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-IRE1p antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | IRE1p |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Accumulation of malfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) and the upregulation of the ER molecular chaperones GRP78 and GRP 94. These proteins are normally bound to ER transmembrane proteins such as IRE1p and ATF6 but ER stress causes their dissociation. This allows IRE1p, a serine-threonine protein kinase to transduce the unfolded protein signal from the ER to the nucleus. IRE1p also has an endoribonuclease activity that is required to splice X-box binding protein (XBP1) mRNA converting it to a potent UPR transcriptional activation. Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs un |
| Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 15 amino acid peptide from near the amino terminus of human IRE1p. |
| Other Names | [Endoplasmic reticulum-to-nucleus signaling 1, ERN1] |
| Gene, Accession # | [IRE1p], Gene ID: 2081, NCBI: NP_001424.3, UniProt: O75460 |
| Catalog # | MBS9406238 |
| Price | $320 |
| Order / More Info | IRE1p Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
Profile of MYBIOSOURCE INC.