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Antigenic Specificity | LCK (C-term), 480-509 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 2 |
Applications | ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This LCK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 480-509 amino acids from the C-terminal region of human LCK. LCK is a member of the Src family of protein tyrosine kinases (PTKs). This protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. |
Immunogen | n/a |
Other Names | [Tyrosine-protein kinase Lck; Leukocyte C-terminal Src kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-LCK; LCK] |
Gene, Accession # | [LCK], Gene ID: 3932, NCBI: NP_001036236.1, UniProt: P06239 |
Catalog # | MBS9200994 |
Price | $165, $370 |
Order / More Info | LCK (C-term), 480-509 Antibody from MYBIOSOURCE INC. |
Product Specific References | Paster,W., J. Immunol. 182 (4), 2160-2167 (2009) Ngai,J., Eur. J. Immunol. 38 (11), 3208-3218 (2008) Strasner,A.B., J. Immunol. 181 (5), 3706-3713 (2008) |