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Antigenic Specificity | Human Collagen alpha-2(IV) chain |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | caprylic acid ammonium sulfate precipitate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Ref.13 Ref.17 Ref.18 Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins. |
Immunogen | n/a |
Other Names | [collagen alpha-2(IV) chain preproprotein; Collagen alpha-2(IV) chain; collagen alpha-2(IV) chain; collagen type IV alpha 2], [COL4A2; COL4A2; ICH; POREN2] |
Gene, Accession # | [COL4A2], Gene ID: 1284, NCBI: NP_001837.2, UniProt: P08572 |
Catalog # | MBS719715 |
Price | $160, $235 |
Order / More Info | Human Collagen alpha-2(IV) chain Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |