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Antigenic Specificity | IPO11 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | biotin conjugate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and |
Immunogen | Immunogen: Recombinant human Importin-11 protein |
Other Names | [Importin-11; Imp11; IPO11; RANBP11; Ran-binding protein 11; RanBP11], [IPO11; IPO11; RanBP11; RANBP11; Imp11; RanBP11] |
Gene, Accession # | [IPO11], Gene ID: 51194, NCBI: NP_001128251.1, UniProt: Q9UI26 |
Catalog # | MBS1492872 |
Price | $160, $235 |
Order / More Info | IPO11 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |