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Antigenic Specificity | PTPRC |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: PTPRC Antibody detects endogenous levels of total PTPRC. The protein phosphatase (PTP) receptor CD45 is a type I transmembrane protein comprised of a pair of intracellular tyrosine phosphatase domains and a variable extracellular domain generated by alternative splicing (1). The catalytic activity of CD45 is a function of the first phosphatase domain (D1) while the second phosphatase domain (D2) may interact with and stabilize the first domain, or recruit/bind substrates (2, 3). CD45 interacts directly with antigen receptor complex proteins or activates Src family kinases involved in the regulation of T-and B-cell antigen receptor signaling (1). Specifically, CD45 dephosphorylates Src-family kinases Lck and Fyn at their conserv |
Immunogen | Immunogen: A synthetic peptide of human PTPRC |
Other Names | [B220; CD45; CD45R; GP180; LCA; LY5; T200] |
Gene, Accession # | [PTPRC], Gene ID: 5788, NCBI: NP_002829.3, UniProt: P08575 |
Catalog # | MBS8516309 |
Price | $290 |
Order / More Info | PTPRC Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |