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Antigenic Specificity | SOCS7 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). |
Immunogen | Immunogen: Recombinant Human Suppressor of cytokine signaling 7 protein (6-165AA) Conjugation: Non-conjugated |
Other Names | [Suppressor of cytokine signaling 7; SOCS-7; Nck; Ash and phospholipase C gamma-binding protein; Nck-associated protein 4; NAP-4; SOCS7; NAP4; SOCS6] |
Gene, Accession # | [SOCS7], Gene ID: 30837, NCBI: NP_055413.1, UniProt: O14512 |
Catalog # | MBS7052417 |
Price | $160, $235 |
Order / More Info | SOCS7 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |