ALS2 (C-term), 1248-1277 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | ALS2 (C-term), 1248-1277 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse (predicted reactivity: rat) |
| Isotype | n/a |
| Format | purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 2 |
| Applications | Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This ALS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1248-1277 amino acids from the C-terminal region of human ALS2. ALS2 contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in its gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. |
| Immunogen | n/a |
| Other Names | [Alsin; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein; Amyotrophic lateral sclerosis 2 protein; ALS2; ALS2CR6; KIAA1563] |
| Gene, Accession # | [ALS2], Gene ID: 57679, NCBI: NP_001129217.1, UniProt: Q96Q42 |
| Catalog # | MBS9202743 |
| Price | $165, $370 |
| Order / More Info | ALS2 (C-term), 1248-1277 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Soares,D.C., J Mol Model 15 (2), 113-122 (2009) Mintchev,N., Neurology 72 (1), 28-32 (2009) |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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