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Antigenic Specificity | PION |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Multiple isoforms of PION are known to exist. PION antibody is predicted to not cross-react with other F-box protein family members. Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The beta amyloid protein precursor (APP) is cleaved by one of two beta secretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99 -amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the Alzheimer's disease patients' brains. PION, or GSAP, selectively increases amyloid-beta production through a mechan |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 19 amino acid peptide near the carboxy terminus of human PION. |
Other Names | [Protein pigeon homolog, gamma-secretase activating protein, GSAP] |
Gene, Accession # | [PION], Gene ID: 54103, NCBI: NP_059135 |
Catalog # | MBS9407328 |
Price | $320 |
Order / More Info | PION Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |