PION Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityPION
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse, rat
Isotypen/a
Formatpeptide affinity purified
Size0.1 mL
Concentrationn/a
ApplicationsELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
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DescriptionSpecificity: Multiple isoforms of PION are known to exist. PION antibody is predicted to not cross-react with other F-box protein family members. Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The beta amyloid protein precursor (APP) is cleaved by one of two beta secretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99 -amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the Alzheimer's disease patients' brains. PION, or GSAP, selectively increases amyloid-beta production through a mechan
ImmunogenImmunogen Type: Peptide Immunogen Description: Raised against a 19 amino acid peptide near the carboxy terminus of human PION.
Other Names[Protein pigeon homolog, gamma-secretase activating protein, GSAP]
Gene, Accession #[PION], Gene ID: 54103, NCBI: NP_059135
Catalog #MBS9407328
Price$320
Order / More InfoPION Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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