APC Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | APC |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 0.05 mL, 0.1 mL |
| Concentration | 1.0 mg/ml |
| Applications | Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The antibody detects endogenous levels of total APC protein. Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.Matthew Bjerknes, Am. J. Pathol., Jun 1999; 154: 1831. T Maltz |
| Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from Internal of human APC. |
| Other Names | [APC; APC protein; Adenomatous polyposis coli protein; DP2.5; mAPC] |
| Gene, Accession # | [APC], Gene ID: 324, NCBI: NP_000029.2, UniProt: P25054 |
| Catalog # | MBS9404074 |
| Price | $200, $255 |
| Order / More Info | APC Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
Profile of MYBIOSOURCE INC.
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