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Antigenic Specificity | rat Cellular tumor antigen p53 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | rat |
Isotype | n/a |
Format | fluorescein (FITC) conjugate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression By similarity. Interacts with GRK5 |
Immunogen | Immunogen: Recombinant rat Cellular tumor antigen p53 protein |
Other Names | [Tumor suppressor p53; TP53], [Tp53; Tp53; p53; Trp53; P53] |
Gene, Accession # | [p53], Gene ID: 24842, NCBI: NP_112251.2, UniProt: P10361 |
Catalog # | MBS719426 |
Price | $160, $235 |
Order / More Info | rat Cellular tumor antigen p53 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |