Edit |   |
---|---|
Antigenic Specificity | APOB |
Clone | [6G6] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | ascites |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defe |
Immunogen | Immunogen: Purified recombinant fragment of human ApoB expressed in E. Coli. |
Other Names | [FLDB; LDLCQ4] |
Gene, Accession # | [APOB], Gene ID: 338, NCBI: CAA28420.1, UniProt: P04114 |
Catalog # | MBS8538783 |
Price | $280 |
Order / More Info | APOB Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |