SIGN-R1, Mouse Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | SIGN-R1, Mouse |
| Clone | ER-TR9 |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgM |
| Format | unconjugated |
| Size | 0.2 mg |
| Concentration | n/a |
| Applications | F, Flow Cytometry (FC/FACS), FS |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Product Description: The monoclonal antibody ER-TR9 recognizes murine SIGN-related 1 (SIGN-R1). Mouse SIGN-R1,- a homolog of human DC-SIGN, is a 37 kDa type II transmembrane protein containing a single, C-terminal C-type lectin domain. SIGN-R1 is a specific marker for the identification of macrophage subpopulations present in the marginal zone of spleen (the so-called marginal zone macrophages (MZM)), in the lymph node medulla, and in the peritoneal cavity of some mouse strains. ER-TR9 does not react with macrophages in other regions of the spleen, such as CD169 marginal metallophils and F4/80 red pulp macrophages. In the spleen, the MZM function in trapping and clearance of blood-borne microbial antigens. SIGN-R1 mediates the uptake of enc |
| Immunogen | Immunogen: Mouse thymic stromal cells |
| Other Names | n/a |
| Gene, Accession # | [SIGN-R1] |
| Catalog # | MBS584242 |
| Price | $520 |
| Order / More Info | SIGN-R1, Mouse Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Dijkstra, C, et al; Marginal zone macrophages identified by a monoclonal antibody: characterization of immune- and enzyme-histochemical properties and functional capacities. Immunology 1985, 55: 23 2. Kretschmer, K, et al; The selection of marginal zone B cells differs from that of B-1a cells. J Immunol 2003, 171: 6495 3. Kang, Y et al; The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide of Streptococcus pneumoniae in the marginal zone of mouse spleen. PNAS 2004, 101: 215 4. Taylor, P et al; The role of SIGN-R1 and the beta-glucan receptor (dectin-1) in the nonopsonic recognition of yeast by specific macrophages. J Immunol 2004, 172: 1157 5. Nagaoka, K et al; Association of SIGNR1 with TLR4-MD-2 enhances signal transduction by recognition of LPS in gram-negative bacteria. Int Immunol 2005, 17: 827 6. Takagi, H et al. Cooperation of specific ICAM-3 grabbing nonintegrin-related 1 (SIGNR1) and complement receptor type 3 (CR3) in the uptake of oligomannose-coated liposomes by macrophages. Glycobiology 2009, 19:258 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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