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Antigenic Specificity | Cyclin D1 (G1-Cyclin & Mantle Cell Lymphoma Marker) |
Clone | [CCND1/2593] |
Host Species | Mouse |
Reactive Species | human. |
Isotype | IgG1, kappa |
Format | purified |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Immunohistology (Formalin-Fixed) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1. |
Immunogen | Immunogen: Recombinant full-length human CCND1 protein Positive Control: T47D, ZR75, BT474, SKBR3, MCF-7, MDA-MB-453, HT29, Ramos, Jurkat or A431 Cells. Mantle cell lymphoma, breast or bladder carcinomas. |
Other Names | [B cell CLL/lymphoma 1; B cell leukemia 1; B-cell lymphoma 1 protein; BCL-1 oncogene; CCND1 protein; CCND1/FSTL3 fusion gene; CCND1/IGHG1 fusion gene CCND1/IGLC1 fusion gene; CCND1/PTH fusion gene; G1/S-specific cyclin-D1, Parathyroid adenomatosis 1, PRAD1 oncogene] |
Gene, Accession # | [CCND1], Gene ID: 595, NCBI: NP_444284.1, UniProt: P24385 |
Catalog # | MBS4380677 |
Price | $190, $340, $340 |
Order / More Info | Cyclin D1 (G1-Cyclin & Mantle Cell Lymphoma Marker) Antibody from MYBIOSOURCE INC. |
Product Specific References | Baldin V; Lukas J; Marcote MJ; Pagano M; Draetta G. Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes and Development, 1993, 7(5):812-21. |