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Antigenic Specificity | SPPL2B |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17965014, PubMed:19114711, PubMed:22194595). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952, PubMed:16829951). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-li |
Immunogen | Immunogen: Recombinant Human Signal peptide peptidase-like 2B protein (492-592AA) |
Other Names | [Signal peptide peptidase-like 2B; Intramembrane protease 41; SPPL2B1 Publication] |
Gene, Accession # | [SPPL2B], Gene ID: 56928, NCBI: NP_001070706.1, UniProt: Q8TCT7 |
Catalog # | MBS7110343 |
Price | $160, $235 |
Order / More Info | SPPL2B Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |