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Antigenic Specificity | Rat Ephrin-A1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | rat |
Isotype | n/a |
Format | biotin conjugate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which lea |
Immunogen | Immunogen: Recombinant Rat Ephrin-A1 protein |
Other Names | [EPH-related receptor tyrosine kinase ligand 1; Immediate early response protein B61; Efna1; Epgl1; Lerk1], [Efna1; Efna1; B61; Epgl1; Lerk1; LERK-1] |
Gene, Accession # | Gene ID: 94268, NCBI: NP_446051.2, UniProt: P97553 |
Catalog # | MBS1488309 |
Price | $160, $235 |
Order / More Info | Rat Ephrin-A1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |