Edit |   |
---|---|
Antigenic Specificity | SOCS1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 2.7 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total SOCS1 protein. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthetic peptide corresponding to residues near the C terminal of human Suppressor of cytokine signaling 1 |
Other Names | [JAB; CIS1; SSI1; TIP3; CISH1; SSI-1; SOCS-1] |
Gene, Accession # | [SOCS1], Gene ID: 8651, NCBI: NP_003736.1, UniProt: O15524 |
Catalog # | MBS9414731 |
Price | $255 |
Order / More Info | SOCS1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |