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Antigenic Specificity | IRS2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human mouse rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: IRS2 Ab detects endogenous levels of total IRS2. Insulin Receptor Substrate 2 (IRS-2) is one of the major substrates of the insulin receptor kinase (1). In vertebrates, IRS-2 functions as a scaffolding protein to coordinate separate branches of the Insulin/IGF-signaling cascades (2). IRS-2 is essential for normal nutrient homeostasis because it mediates both peripheral insulin action and the effect of IGF-1 on B-cell growth. Mice lacking IRS-2 fail to maintain sufficient compensatory insulin secretion and develop diabetes as young adults |
Immunogen | Immunogen: Recombinant protein of human IRS2 Subcellular Location: Cytoplasm > Cytosol |
Other Names | [Insulin Receptor Substrate 2; IRS 2;IRS2_HUMAN] |
Gene, Accession # | [IRS2], Gene ID: 8660, NCBI: NP_003740.2, UniProt: Q9Y4H2 |
Catalog # | MBS9385623 |
Price | $440, $715 |
Order / More Info | IRS2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |