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Antigenic Specificity | NTF3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | NT-3 is a member of the structurally related neurotrophin family of proteins, which includes beta-NGF, BDNF and NT-4 (1). NT-3 is expressed in a number of cell types including neuronal cells, eosinophils, and melanocytes (1-3). NT-3 is required for the development of peripheral sensory neurons (4). NT-3 is secreted from cells as a precursor protein, which is proteolytically cleaved into the mature form (1). NT-3 signaling is mediated through two distinct receptors, the neurotrophin receptor p75NTR and the Trk tyrosine kinase receptor TrkC. While all neurotrophins bind to the p75NTR receptor, NT-3 preferentially binds to TrkC and, with lesser affinity, TrkB (1). |
Immunogen | Immunogen: Recombinant protein of human NTF3 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [NTF3; HDNF; MGC129711; NGF-2; NGF2; NT3] |
Gene, Accession # | [NTF3], Gene ID: 4908, NCBI: NP_001096124.1, UniProt: P20783 |
Catalog # | MBS8502856 |
Price | $310 |
Order / More Info | NTF3 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Huang, E.J. and Reichardt, L.F. (2001) Annu Rev Neurosci 24, 677-736. 2. Noga, O. et al. (2003) Clin Exp Allergy 33, 649-54. 3. Truzzi, F. et al. (2008) J Invest Dermatol 128, 2031-40. 4. Tessarollo, L. et al. (1994) Proc Natl Acad Sci U S A 91, 11844-8. |