Phospho-Mapt-S416 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityPhospho-Mapt-S416
Clonepolyclonal
Host SpeciesRabbit
Reactive Speciesmouse, rat
Isotypen/a
Formataffinity purified
Size0.05 mL, 0.1 mL, 0.2 mL
Concentration1mg/ml
ApplicationsWestern Blot (WB)
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DescriptionTau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5 (1-2). Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation of Ser396 by GSK-3 or CDK5 destabilizes microtubules in Alzheimer's disease. Furthermore, inclusions of tau are found in a number of o
ImmunogenImmunogen: A phospho specific peptide corresponding to residues surrounding S416 of Rat Mapt Calculated Molecular Weight: 48/62/78kDa
Other Names[Phospho-Mapt-S416: pTau; Mtapt; RNPTAU], [Mapt; Mapt; pTau; Mtapt; RNPTAU; Mtapt; Tau; PHF-tau]
Gene, Accession #[Mapt], Gene ID: 29477, NCBI: P19332.3, UniProt: P19332
Catalog #MBS128389
Price$235, $350, $525
Order / More InfoPhospho-Mapt-S416 Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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