Cyclin-dependent kinase 4 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Cyclin-dependent kinase 4 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | caprylic acid ammonium sulfate precipitate |
| Size | 0.1 mL |
| Concentration | 1.0 mg/ml |
| Applications | Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The antibody detects endogenous level of total Cyclin-dependent kinase 4 polyclonal antibody. Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional act |
| Immunogen | Immunogen: Recombinant Human Cyclin-dependent kinase 4 |
| Other Names | [Cell division protein kinase 4; PSK-J3; CDK4] |
| Gene, Accession # | Gene ID: 1019, NCBI: NP_000066.1, UniProt: P11802 |
| Catalog # | MBS9416344 |
| Price | $320 |
| Order / More Info | Cyclin-dependent kinase 4 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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