ENaC Beta Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-ENaC Beta antibody, protein, ELISA kits.
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|---|---|
| Antigenic Specificity | ENaC Beta |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | Humna, mouse, rat |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | 1 mg/ml |
| Applications | Western (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Background Info: Detects ~87kDa. Scientific Background: The Epithelial Sodium Channel (ENaC) is a membrane ion channel permeable to Na ions. It is located in the apical plasma membrane of epithelia in the kidneys, lung, colon, and other tissues where it plays a role in trans epithelial Na -ion transport (1). Specifically Na transport via ENaC occurs across many epithelial surfaces, and plays a key role in regulating salt and water absorption (2). ENaCs are composed of three structurally related subunits that form a tetrameric channel, alpha, beta, and gamma. The expression of its alpha and beta subunits is enhanced as keratinocytes differentiate (3, 4). The beta and gamma-ENaC subunits are essential for edema fluid to exert its maximal effe |
| Immunogen | Immunogen: Produced against the C-terminal tail (amino acids 617-638) of rat beta ENaC (antibody designation 3755-2). Research Areas: Neuroscience; Ion Channels; Sodium Channels; Epithelial Sodium Channels (ENaC). Cellular Localization: Apical Cell Membrane |
| Other Names | [SCNN1B, Amiloride sensitive sodium channel subunit beta, Amiloride-sensitive sodium channel beta-subunit, Beta ENaC, Beta NaCH, ENaC beta, ENaCB, Epithelial Na(+) channel subunit beta, Epithelial Na+ channel beta subunit, Epithelial Na+ channel subunit beta, Epithelial sodium channel beta 2 subunit, Epithelial sodium channEl beta 3 subunit AntiGGJ; Ncnvoltage gClted sodium channell beta subunit, Nonvoltage gated sodium channell subunit beta, Nonvoltage-gated sodium channell beta subunit, SCNEB, SCNN 1B, Sodium channel nonvoltage gated 1 beta (Liddle syndrome), Sodium channel nonvoltage gated 1 beta Neuroscience I Ion Channels I Sodium Channels I Epithelial Sodium Channels], [Scnn1b; Scnn1b; RNENACB; Beta-ENaC] |
| Gene, Accession # | Gene ID: 24767, NCBI: NP_036780, UniProt: P37090 |
| Catalog # | MBS806568 |
| Price | $445 |
| Order / More Info | ENaC Beta Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Kakizoe Y., et al. (2009) J Hpyertens. 27(8): 1679-1689. 2. Gu Y. (2008) J Cell Physiol. 216(2):453-457. 3. Bruns J.B. (2003) Am J Physiol Renal Physiol. 285(4): F600-F609. 4. Mauro T., et al. (2002) J Invest Dermatol. 118(4): 589-594. 5. Elias N., et al. (2007) Am J Physiol Lung Cell Mol Physiol. 293(3): L537-45. 6. Dyka F.M., May C.A. and Enz R. (2005) J Neurochem. 94(1): 120-128.1. Ilatovskaya, D.V., Pavlov, T.S., Levchenko, V., Negulyaev, Y.A. and Staruschenko, A. (2011). Cortical actin binding protein cortactin mediates ENaC activity via Arp2/3 complex. The FASEB Journal. 25 (8), 2688-2699. doi: 10.1096/fj.10-167262 2. Edinger, R.S. et al. (2012). The Epithelial Sodium Channel (ENaC) Establishes a Trafficking Vesicle Pool Responsible for Its Regulation. PLoS ONE. 7(9): e46593. doi: 10.1371/journal.pone.0046593 3. van der Lubbe, N. et al. (2012). Aldosterone does not require angiotensin II to activate NCC through a WNK4-SPAK-dependent pathway. Euro J Physiol. 463 (6), 853-863. doi:10.1007/s00424-012-1104-0 |
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MYBIOSOURCE INC.
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