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Antigenic Specificity | C-Fos (7D6) |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | human, rat, monkey |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody detects endogenous levels of c-Fos and does not cross-react with related proteins. Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor.In the heterodimer,FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites.On TGF-beta activation,forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling.Has a critical function in regulating the development of cells destined to form and maintain the skeleton.It is thought to have an important role in signal transduction,cell proliferation and differentiation.In growing cells,activates phospholipid synthesis,possibly by activating CDS1 and PI4 |
Immunogen | Immunogen: Purified recombinant human FOS protein fragments expressed in E Coli. |
Other Names | [Activator protein 1; AP 1; Cellular oncogene c fos; Cellular oncogene fos; FBJ murine osteosarcoma viral (v fos) oncogene homolog (oncogene FOS); FBJ murine osteosarcoma viral v fos oncogene homolog; FBJ Osteosarcoma Virus; FOS; FOS protein; FOS_HUMAN; G0 G1 switch] |
Gene, Accession # | [C-Fos], Gene ID: 2353, NCBI: NP_005243.1, UniProt: P01100 |
Catalog # | MBS4751603 |
Price | $335 |
Order / More Info | C-Fos (7D6) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |