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Antigenic Specificity | CD11b/MAC-1 (Microglial Marker) |
Clone | [ITGAM/271] |
Host Species | Mouse |
Reactive Species | human. |
Isotype | IgG1, kappa |
Format | unconjugated |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: CD11b is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin aM combines with the Integrin ?2 to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). Integrin aM/?2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. The protein CD11b has been implicated in the various adhesion-related interactions of cells such as monocytes, macrophages, natural killer (NK) cells, and granulocytes. It is part |
Immunogen | Immunogen: Recombinant human ITGAM protein Cellular Localization: Cell Surface |
Other Names | [CD11 antigen-like family member B; CD11b/CD18; CD49d; Cell surface glycoprotein MAC-1 subunit alpha; Complement Component Receptor 3 Alpha; CR3 Alpha Chain (CR3A); Integrin alpha-M; Integrin beta 2 alpha subunit; ITGAM; Leukocyte adhesion receptor MO1; Ly-40; Mac-1a; MAC1; Mac1, alpha subunit; MAC1A; Macrophage antigen alpha polypeptide; MO1A; Neutrophil adherence receptor alpha M subunit] |
Gene, Accession # | [CD11b], Gene ID: 3684, NCBI: NP_000623.2, UniProt: P11215 |
Catalog # | MBS4380050 |
Price | $190, $340, $340 |
Order / More Info | CD11b/MAC-1 (Microglial Marker) Antibody from MYBIOSOURCE INC. |
Product Specific References | Springer T, et al. 1978. Eur. J. Immunol. 8:539. Ault K and Springer T. 1981. J. Immunol. 126:359. Springer TA, et al. 1982. Immunol. Rev. 68:171. Ho MK and Springer TA. 1983. J. Biol. Chem. 258:2766. Flotte TJ, et al. 1983. Am. J. Pathol. 111:112. |