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Antigenic Specificity | FZD1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differen |
Immunogen | Immunogen: Recombinant Human Frizzled-1 protein (73-322AA) Conjugation: Non-conjugated |
Other Names | [Frizzled-1; Fz-1; hFz1; FzE1; FZD1] |
Gene, Accession # | [FZD1], Gene ID: 8321, NCBI: NP_003496.1, UniProt: Q9UP38 |
Catalog # | MBS7053361 |
Price | $160, $235 |
Order / More Info | FZD1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |