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Antigenic Specificity | Rec.Pr.Thyrosin Phosphate (RPTP) |
Clone | [3D7] |
Host Species | Mouse (Balb/c) |
Reactive Species | human, rat, porcine |
Isotype | IgG2a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Monoclonal antibodies 3G4 and 3D7 have been directed anti the extracellular domain of RPTPu. Receptor-like protein tyrosine phosphatases (RPTPs) represent a new family of transmembrane proteins that are thought to transduce external signals by dephosphorylating phosphotyrosine residues on intracellular substRates. RPTPu is a prototypic receptor-like protein-tyrosine phosphatase (RPTP) that mediates homotypic cell-cell interactions. Intracellularly, RPTPu consists of a relatively large juxtamembrane region (about 150 amino acids) and two conserved phosphatase domains. As in most RPTPs, the first (membrane-proximal) PTP domain of RPTPu is Catalytically active, whereas its second (C-terminal) domain is inactive. RPTPu is involved |
Immunogen | Source Note: 3D7 is a Mouse monoclonal IgG2a antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with ExG protein, secreted by NIH-3T3 transfected cells and purified with glutahione beads. The cells have been transfected using a fusion construct, termed ExG, encoding the entire ectodomain of the Human RPTPu molecule (aa 1-742), fused COOH terminally to GST. |
Other Names | n/a |
Gene, Accession # | n/a |
Catalog # | MBS570235 |
Price | $770 |
Order / More Info | Rec.Pr.Thyrosin Phosphate (RPTP) Antibody from MYBIOSOURCE INC. |
Product Specific References | Gerben C. M. Zondag, Albert B. Reynolds , and Wouter H. Moolenaar. THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 275, No. 15, Issue of April 14, pp. 11264-11269, 2000. |