TICAM1 (N-term), 115-143 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | TICAM1 (N-term), 115-143 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.5 |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This TICAM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-143 amino acids from the N-terminal region of human TICAM1. Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. |
| Immunogen | n/a |
| Other Names | [TIR domain-containing adapter molecule 1; TICAM-1; Proline-rich; vinculin and TIR domain-containing protein B; Putative NF-kappa-B-activating protein 502H; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; MyD88-3; TIR domain-containing adapter protein inducing IFN-beta; TICAM1; PRVTIRB; TRIF] |
| Gene, Accession # | [TICAM1], Gene ID: 148022, NCBI: NP_891549.1, UniProt: Q8IUC6 |
| Catalog # | MBS9206974 |
| Price | $165, $370 |
| Order / More Info | TICAM1 (N-term), 115-143 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Bin L.-H., et al. J. Biol. Chem. 278:24526-24532(2003). Yamamoto M., et al. J. Immunol. 169:6668-6672(2002). Oshiumi H., et al. Nat. Immunol. 4:161-167(2003). Nakajima T., et al. Immunogenetics 60:727-735(2008). Matsuda A., et al. Oncogene 22:3307-3318(2003). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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