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Antigenic Specificity | CASP12 - middle region |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced trans |
Immunogen | Immunogen: The immunogen is a synthetic peptide directed towards the middle terminal region of human CASP12 |
Other Names | [inactive caspase-12; Inactive caspase-12; inactive caspase-12; caspase 12 (gene/pseudogene)] |
Gene, Accession # | [CASP12], Gene ID: 100506742, NCBI: NP_001177945.2, UniProt: Q6UXS9 |
Catalog # | MBS3223155 |
Price | $335 |
Order / More Info | CASP12 - middle region Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |