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Antigenic Specificity | Human TrkA/NTRK1 |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | IgG |
Format | unconjugated |
Size | 0.06 mL, 0.12 mL, 0.2 mL |
Concentration | n/a |
Applications | Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. It is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors. The presence of NTRK1 leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TRKA gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. |
Immunogen | Immunogen: Recombinant Human TrkA/NTRK1 protein Buffer: 0.2 mum filtered solution in PBS with 5% trehalose |
Other Names | [TRKA; High affinity nerve growth factor receptor; high affinity nerve growth factor receptor; neurotrophic receptor tyrosine kinase 1; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A; Trk-A; gp140trk; p140-TrkA] |
Gene, Accession # | [TrkA/NTRK1 ], Gene ID: 4914 |
Catalog # | MBS2544163 |
Price | $215, $330, $500 |
Order / More Info | Human TrkA/NTRK1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |