PTPN22 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | PTPN22 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | PTPN22 (Lyp/PEP) is a cytoplasmic phosphatase expressed by hematopoietic cells (1, 2). PTPN22 associates with the tyrosine kinase Csk to inhibit T cell receptor signaling through inactivation of Src kinases (3, 4). Csk phosphorylates Src kinases on an inhibitory tyrosine, while PTPN22 dephosphorylates an activating site (4). PTPN22(-/-) mice have higher levels of activated Lck than wild-type, resulting in greater T cell expansion and increased serum antibody levels (5). Research studies have shown that a single-nucleotide polymorphism, 1858T of the PTPN22 gene which encodes the amino acid substitution R620W, confers increased risk for multiple autoimmune diseases including type I diabetes, rheumatoid arthritis, systemic lupus erythematosus, |
| Immunogen | Immunogen: Recombinant protein of human PTPN22 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [LYP; LYP1; LYP2; PEP; PTPN8; PTPN22] |
| Gene, Accession # | [PTPN22], Gene ID: 26191, NCBI: NP_001180360.1, UniProt: Q9Y2R2 |
| Catalog # | MBS8501088 |
| Price | $310 |
| Order / More Info | PTPN22 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Cohen, S. et al. (1999) Blood 93, 2013-24. 2. Matthews, R.J. et al. (1992) Mol Cell Biol 12, 2396-405. 3. Cloutier, J.F. and Veillette, A. (1996) EMBO J 15, 4909-18. 4. Cloutier, J.F. and Veillette, A. (1999) J Exp Med 189, 111-21. 5. Hasegawa, K. et al. (2004) Science 303, 685-9. 6. Bottini, N. et al. (2004) Nat Genet 36, 337-8. 7. Begovich, A.B. et al. (2004) Am J Hum Genet 75, 330-7. 8. Kyogoku, C. et al. (2004) Am J Hum Genet 75, 504-7. 9. Velaga, M.R. et al. (2004) J Clin Endocrinol Metab 89, 5862-5. 10. Vang, T. et al. (2005) Nat Genet 37, 1317-9. 11. Rieck, M. et al. (2007) J Immunol 179, 4704-10. 12. Zhang, J. et al. (2011) Nat Genet 43, 902-7. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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