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Antigenic Specificity | CBX7 (C-term) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This CBX7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 168-201 amino acids from the C-terminal region of human CBX7. Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintai |
Immunogen | n/a |
Other Names | [Chromobox protein homolog 7; CBX7] |
Gene, Accession # | [CBX7], Gene ID: 23492, NCBI: NP_783640.1, UniProt: O95931 |
Catalog # | MBS9212895 |
Price | $165, $370 |
Order / More Info | CBX7 (C-term) Antibody from MYBIOSOURCE INC. |
Product Specific References | Dunham I.,et al.Nature 402:489-495(1999). Gil J.,et al.Nat. Cell Biol. 6:67-72(2004). Bezsonova I.,et al.Biochemistry 48:10542-10548(2009). Maertens G.N.,et al.PLoS ONE 4:E6380-E6380(2009). Li Q.,et al.PLoS ONE 5:E13732-E13732(2010). |