NPC1L1 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | NPC1L1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: NPC1L1 antibody detects endogenous levels of total NPC1L1. Function: Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation.Subunit Structure: Interacts with RAB11A, MYO5B and RAB11FIP2. Intera |
| Immunogen | Immunogen: A synthesized peptide derived from human NPC1L1 Subcellular Location: Plasma Membrane Tissue Specificity: Widely expressed. Expressed in liver. Also expressed in small intestine, pancreas, kidney, lung, pancreas, spleen, heart, gall bladder, brain, testis, stomach and muscle. Predicted Cross Reactivity: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus Similarity: Pig (100%), Zebrafish (80%), Bovine (90%), Horse (100%), Sheep (90%), Rabbit (90%), Dog (90%), Xenopus (90%) |
| Other Names | [Niemann Pick C1 like protein 1; Niemann Pick disease type C1 gene like 1; Niemann-Pick C1-like protein 1; NPC1 LIKE 1; NPC1 Niemann Pick disease type C1 gene like 1; NPC1L1; NPC1L1 splice variant; NPCL1_HUMAN; Truncated Niemann Pick C1 like protein 1] |
| Gene, Accession # | [NPC1L1], Gene ID: 29881, NCBI: NP_001095118.1, UniProt: Q9UHC9 |
| Catalog # | MBS9608802 |
| Price | $240, $280 |
| Order / More Info | NPC1L1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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