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Antigenic Specificity | OPTN |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total OPTN protein. This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human OPTN. |
Other Names | [NRP; FIP2; HIP7; HYPL; ALS12] |
Gene, Accession # | [OPTN], Gene ID: 10133, NCBI: NP_001008212.1, UniProt: Q96CV9 |
Catalog # | MBS9409041 |
Price | $255 |
Order / More Info | OPTN Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |