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Antigenic Specificity | RCOR1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peroxidase (HRP) conjugate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone |
Immunogen | Immunogen: Recombinant human REST corepressor 1 protein |
Other Names | [REST corepressor 1; Protein CoREST; RCOR1; KIAA0071; RCOR] |
Gene, Accession # | [RCOR1], Gene ID: 23186, NCBI: NP_055971.2, UniProt: Q9UKL0 |
Catalog # | MBS7044265 |
Price | $160, $235 |
Order / More Info | RCOR1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |