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Antigenic Specificity | (Mouse) Sox17 (C-term) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This (Mouse) Sox17 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 376-409 amino acids from the C-terminal region of mouse Sox17. Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'- AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells. Isoform 2 (T-SOX17) shows no DNA-binding activity. |
Immunogen | n/a |
Other Names | [Transcription factor SOX-17; Sox17; Sox-17] |
Gene, Accession # | [Sox17], Gene ID: 20671, NCBI: NP_001276393.1, UniProt: Q61473 |
Catalog # | MBS9215277 |
Price | $165, $370 |
Order / More Info | (Mouse) Sox17 (C-term) Antibody from MYBIOSOURCE INC. |
Product Specific References | Kanai Y.,et al.J. Cell Biol. 133:667-681(1996). Carninci P.,et al.Science 309:1559-1563(2005). Layfield R.,et al.Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases. Kanai-Azuma M.,et al.Development 129:2367-2379(2002). Kim I.,et al.Cell 130:470-483(2007). |