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Antigenic Specificity | BK Beta3a |
Clone | [S40B-18] |
Host Species | Mouse |
Reactive Species | human, mouse, rat |
Isotype | IgG1 |
Format | PE-ATTO 594 conjugate |
Size | 0.1 mg |
Concentration | 1mg/mL |
Applications | Western (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Background Info: Detects ~32 kDa. No cross-reactivity against BKBeta1, BKBeta2, BKBeta3b or BKBeta4. Scientific Background: BK channels contribute to electrical impulses, proper signal transmission of information and regulation of neurotransmitter release (3). A gain of function mutation in the pore-forming alpha subunit of the BK channel was linked to human neurological diseases. Findings suggest that the distribution of the beta subunits in the brain can modulate the BK channels to contribute to the pathophysiology of epilepsy and dyskinesia (4). This has major implications on other physiological processes in tissues other than the brain. |
Immunogen | n/a |
Other Names | [HBETA3; KCNMB2; KCNMBL; BKBeta3; KCNMB3; Calcium-activated potassium channel subunit beta-3; BK channel subunit beta-3; BKbeta3; Hbeta3; Calcium-activated potassium channel; subfamily M subunit beta-3 Charybdotoxin receptor subunit beta-3; K(VCA)beta-3], [KCNMB3; KCNMB3; HBETA3; KCNMB2; KCNMBL; BKBETA3; SLOBETA3; SLO-BETA-3; K(VCA)BETA-3; KCNMB2; KCNMBL; BKbeta3; Hbeta3] |
Gene, Accession # | Gene ID: 27094, NCBI: NP_055222.3, UniProt: Q9NPA1 |
Catalog # | MBS800064 |
Price | $445 |
Order / More Info | BK Beta3a Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.: Sunderland, MA USA. 2. www.iochannels.org 3. Wulf-Johansson H., et al. (2009) Brain Res. 1292: 1- 13. 4. Lee U.S., and Cui J. (2009) J Physiol. 587(7): 1481- 1489. |