BBC3(PUMA) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | BBC3(PUMA) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: BBC3(PUMA) antibody detects endogenous levels of total BBC3(PUMA). Function: Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis.Subunit Structure: Interacts with MCL1 and BCL2A1 (By similarity). Interacts with BCL2 and BCL2L1/BCL-XL. Interacts (via BH3 domain) with NOL3 (via CARD domain); preventing the association of BBC3 with BCL2 and resulting in activation of CASP8 (By similarity).Similarity: The BH3 motif is intrinsically disordered. Belongs to the Bcl-2 family. |
| Immunogen | Immunogen: A synthesized peptide derived from human BBC3(PUMA) Subcellular Location: Mitochondrion. Localized to the mitochondria in order to induce cytochrome c release. Tissue Specificity: Ubiquitously expressed. Predicted Cross Reactivity: Pig, Dog Similarity: Pig (100%), Dog (100%) |
| Other Names | [BBC 3; Bbc3; BBC3_HUMAN; BCL 2 binding component 3; Bcl-2-binding component 3; BCL2 binding component 3; JFY 1; JFY-1; JFY1; p53 up regulated modulator of apoptosis; p53 up-regulated modulator of apoptosis; p53 Upregulated Modulator of Apoptosis; PUMA alpha; PUMA/JFY1] |
| Gene, Accession # | [BBC3], Gene ID: 27113, NCBI: NP_001120712.1, UniProt: Q9BXH1 |
| Catalog # | MBS9601346 |
| Price | $240, $280 |
| Order / More Info | BBC3(PUMA) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Zhang D, Li Y, Wang R, Li Y, Shi P, Kan Z, Pang X; Journal: Int J Mol Sci. Inhibition of REST Suppresses Proliferation and Migration in Glioblastoma Cells. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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