RFX1 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | RFX1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mg |
| Concentration | 1 mg/mL |
| Applications | ELISA (EIA), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: RFX1 antibody is human specific. At least two isoforms of RFX1 are known to exist; this antibody will detect both isoforms. RFX1 is a member of the regulatory factor X protein family, which are transcription factors that contain a highly-conserved winged helix DNA binding domain and the D region found in the C-terminal part of these proteins which facilitates dimerization (1,2). RFX1 is structurally related to regulatory factors X2, X3, X4, and X5 (3). RFX1 is a regulatory factor essential for MHC class II genes expression and can bind to an inverted repeat that is required for expression of hepatitis B virus genes (4). Recent study identifies RFX1 may play a tumor suppressor role in HCC as autophagy mediator (5). |
| Immunogen | Immunogen: RFX1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human RFX1. Buffer: Supplied in PBS containing 0.02% sodium azide. Positive Control 1: HeLa Cell Lysate |
| Other Names | [Regulatory factor X, 1 (influences HLA class II expression); RFX; MHC class II regulatory factor RFX; MHC class II regulatory factor RFX1; enhancer factor C; EFC; trans-acting regulatory factor 1; transcription factor RFX1], [RFX1; RFX1; EFC; RFX; EF-C; RFX] |
| Gene, Accession # | [RFX1], Gene ID: 5989, NCBI: NP_002909, UniProt: P22670 |
| Catalog # | MBS154374 |
| Price | $375 |
| Order / More Info | RFX1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Reith W, Ucla C, Barras E, et al. RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. Mol. Cell Biol. 1994; 14:1230-44. Katan-Khaykovich Y and Shaul Y. RFX1, a single DNA-binding protein with a split dimerization domain, generates alternative complexes. J. Biol. Chem. 1998; 273:24504-12. Hsu YC, Liao WC, Kao CY, et al. Regulation of FGF1 gene promoter through transcription factor RFX1. J. Biol. Chem. 2010; 285:13885-95. Su JC, Tseng PH, Hsu CY, et al. RFX1-dependent activation of SHP-1 induces autophagy by a novel obatoclax derivative in hepatocellular carcinoma cells. Oncotarget 2014; 5:4909-19. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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