Edit |   |
---|---|
Antigenic Specificity | XEDAR |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | X-linked ectodysplasin-A2 receptor (XEDAR) is a recently isolated member of the tumor necrosis factor receptor family that is highly expressed during embryonic development and binds to ectodysplatin-A2 (EDA-A2). Two predominantly expressed isoforms, XEDAR-s and XEDAR-L, differ by only a 21-amino region at the juxtamembrane region of the cytoplasmic domain. Neither isoform possesses a death domain and both have been shown to act mainly through TRAF3 and TRAF6 to activate the NF-kB and JNK pathways. Cells transfected with XEDAR and treated with EDA-A2 cause the assembly of a secondary complex containing FADD, caspase-8 and caspase-10, leading to the activation caspase-8 and caspase-3, and finally apoptosis. The EDA-A2-induced apoptosis is dep |
Immunogen | Immunogen Type: Recombinant protein Immunogen Description: Raised against recombinant human XEDAR. |
Other Names | [X-linked ectodysplasin-A2 receptor, EDA-A2 receptor, TNFRSF27] |
Gene, Accession # | [XEDAR], Gene ID: 60401, NCBI: AAQ89953 |
Catalog # | MBS9400697 |
Price | $320 |
Order / More Info | XEDAR Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |