SQSTM1 (p62) (C-term) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | SQSTM1 (p62) (C-term) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human,mouse,ratpredicted: rat |
| Isotype | n/a |
| Format | purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | n/a |
| Applications | WB, IHC-P , IF, E |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This SQSTM1 (p62) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 317-346 amino acids from the C-terminal region of human SQSTM1 (p62). SQSTM1/p62 is an adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. This protein may play a role in titin/TTN downstream signaling in muscle cells, and may also regulate signaling cascades through ubiquitination. This protein is involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. SQSTM1/p62 also appears to play a role in macroautophagic removal of intracellular protein aggregates. Cellular depletion studies of SQSTM1/p62 have indicated |
| Immunogen | n/a |
| Other Names | [Sequestosome-1; EBI3-associated protein of 60 kDa; EBIAP; p60; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; Ubiquitin-binding protein p62; SQSTM1; ORCA; OSIL] |
| Gene, Accession # | [SQSTM1], Gene ID: 8878, NCBI: NP_001135770.1, UniProt: Q13501 |
| Catalog # | MBS9204361 |
| Price | $165, $370 |
| Order / More Info | SQSTM1 (p62) (C-term) Antibody from MYBIOSOURCE INC. |
| Product Specific References | References for protein: 1.Seibenhener, M.L., et al., Mol. Cell. Biol. 24(18):8055-8068 (2004). 2.Eekhoff, E.W., et al., Arthritis Rheum. 50(5):1650-1654 (2004). 3.Brajenovic, M., et al., J. Biol. Chem. 279(13):12804-12811 (2004). 4.Kuusisto, E., et al., J. Neuropathol. Exp. Neurol. 62(12):1241-1253 (2003). 5. Johnson-Pais, T.L., et al., J. Bone Miner. Res. 18(10):1748-1753 (2003). References for U251 cell line: 1. Westermark B.; Ponten J.; Hugosson R. (1973). Determinants for the establishment of permanent tissue culture lines from human gliomas. Acta Pathol Microbiol Scand A. 81:791-805. [PMID: 4359449]. 2. Ponten, J.,Westermark B. (1978). Properties of Human Malignant Glioma Cells in Vitro. Medical Biology 56: 184-193.[PMID: 359950]. 3. Geng Y.;Kohli L.; Klocke B.J.; Roth K.A.(2010). Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent. Neuro Oncol. 12(5): 473-481.[ PMID: 20406898]. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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