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Antigenic Specificity | CHCHD4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: CHCHD4 antibody detects endogenous levels of CHCHD4. Function: Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17, COX19 and MICU1 (PubMed:16185709, PubMed:26387864, PubMed:19182799, PubMed:21059946, PubMed:23186364, PubMed:23676665). Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular |
Immunogen | Immunogen: A synthesized peptide derived from human CHCHD4. Subcellular Location: Mitochondrion Intermembrane Space. Tissue Specificity: Expressed in all tissues tested, suggesting an ubiquitous expression. Predicted Cross Reactivity: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus Similarity: Pig (92%), Zebrafish (83%), Bovine (92%), Horse (92%), Sheep (92%), Rabbit (92%), Dog (92%), Chicken (92%), Xenopus (92%) |
Other Names | [CHCHD4; Coiled coil helix coiled coil helix domain containing 4; Coiled coil helix coiled coil helix domain containing protein 4; Coiled-coil-helix-coiled-coil-helix domain-containing protein 4; FLJ31709; MIA40_HUMAN; Mitochondrial intermembrane space import and assembly 40 homolog; Mitochondrial intermembrane space import and assembly protein 40; TIMM40; Translocase of inner mitochondrial membrane 40 homolog] |
Gene, Accession # | [CHCHD4], Gene ID: 131474, NCBI: NP_001091972.1, UniProt: Q8N4Q1 |
Catalog # | MBS9603592 |
Price | $240, $280 |
Order / More Info | CHCHD4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |