Major Vault Protein (MVP) Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | Major Vault Protein (MVP) |
| Clone | [VP2897R] |
| Host Species | Rabbit |
| Reactive Species | human. |
| Isotype | IgG |
| Format | purified |
| Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
| Concentration | n/a |
| Applications | Immunohistology (Formalin-Fixed) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Recognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a |
| Immunogen | Immunogen: Recombinant full-length human MVP protein Positive Control: MCF-7 or HeLa Cells. Breast tumors |
| Other Names | [Lung resistance-related protein (LRP); Major Vault Protein; MVP; VAULT1] |
| Gene, Accession # | [MVP], Gene ID: 9961, NCBI: NP_001280133.1, UniProt: Q14764 |
| Catalog # | MBS4380752 |
| Price | $190, $340, $340 |
| Order / More Info | Major Vault Protein (MVP) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Abbondanza C, Rossi V, Roscigno A, Gallo L, Belsito A, Piluso G, Medici N, Nigro V, Molinari AM, Moncharmont B, Puca GA: Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell. J Cell Biol 1998; 141(6):1301-1310.; Den Boer, M.L. et al. Relationship between major vault protein/lung resistance protein, multidrug resistance-associated protein, P-glycoprotein expression, and drug resistance in childhood leukemia. Blood 91, 2092-2098 (1998). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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