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Antigenic Specificity | CENPR |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: CENPR antibody detects endogenous levels of total CENPR. Function: Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a cas |
Immunogen | Immunogen: A synthesized peptide Subcellular Location: Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Cytoplasm. Isoform 4: Cytoplasm. Note=Localizes in the centromeres. Isoform 3 is predominantly nuclear and weakly cytoplasmic. Tissue Specificity: Widely expressed. Expressed in spleen, thymus, prostate, ovary, small intestine and white blood cells. Highly expressed in testis and colon. Isoform 4 is expressed in platelets, lymphocytes and granulocytes. Predicted Cross Reactivity: Do |
Other Names | [Beta 3 endonexin; Beta3 endonexin; Beta3 endonexin long form; CENP R; CENPR; CENPR_HUMAN; Centromere protein R; endonexin, Beta-3; HSU37139; Integrin beta 3 binding protein (beta3-endonexin); Integrin beta 3 binding protein; NRIF 3; NRIF3; Nuclear receptor interacting factor 3; TAP 20; TAP20] |
Gene, Accession # | [CENPR], Gene ID: 23421, NCBI: NP_001193668.1, UniProt: Q13352 |
Catalog # | MBS9603848 |
Price | $240, $280 |
Order / More Info | CENPR Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |