Phospho-MAP2K1-S217 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-MAP2K1-S217 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | MEK1 and MEK2, also called MAPK or Erk kinases, are dual-specificity protein kinases that function in a mitogen activated protein kinase cascade controlling cell growth and differentiation (1-3). Activation of MEK1 and MEK2 occurs through phosphorylation of two serine residues at positions 217 and 221, located in the activation loop of subdomain VIII, by Raf-like molecules. MEK1/2 is activated by a wide variety of growth factors and cytokines and also by membrane depolarization and calcium influx (1-4). Constitutively active forms of MEK1/2 are sufficient for the transformation of NIH/3T3 cells or the differentiation of PC-12 cells (4). MEK activates p44 and p42 MAP kinase by phosphorylating both threonine and tyrosine residues at sites loc |
| Immunogen | Immunogen: A phospho specific peptide corresponding to residues surrounding S217 of human MAP2K1 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [MEK1; MKK1; MAPKK1; PRKMK1] |
| Gene, Accession # | [MAP2K1-S217], Gene ID: 5604, NCBI: NP_002746.1, UniProt: Q02750 |
| Catalog # | MBS8527441 |
| Price | $310 |
| Order / More Info | Phospho-MAP2K1-S217 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Crews, C.M. et al. (1992) Science 258, 478-480. 2. Alessi, D.R. et al. (1994) EMBO J. 13, 1610-1619. 3. Rosen, L.B. et al. (1994) Neuron 12, 1207-1221. 4. Cowley, S. et al. (1994) Cell 77, 841-852. 5. Xu, B. et al. (1999) J. Biol. Chem. 274, 34029-34035. 6. Coles, L.C. and Shaw, P.E. (2002) Oncogene 21, 2236-2244. 7. Eblen, S. T. et al. (2002) Mol. Cell. Biol. 22, 6023-6033. 8. Sharma, P. et al. (2002) J. Biol. Chem. 277, 528-534. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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