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Antigenic Specificity | SETDB1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.02 mL, 0.06 mL, 0.12 mL |
Concentration | 1.08mg/mL |
Applications | Immunohistochemistry (IHC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | SETDB1, also named as ESET, KIAA0067 and KMT1E, belongs to the histone-lysine methyltransferase family. It is a SET domain protein with histone H3-K9-specific methyltransferase activity. H3 'Lys-9' trimethylation is coordinated with DNA methylation and represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. SETDB1 mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. It probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by bein |
Immunogen | Immunogen: Fusion protein of human SETDB1 |
Other Names | [AU022152; EC 2.1.1.43; ERG-associated protein with SET domain; ESET; H3 K9 HMTase 4; H3-K9-HMTase 4; H3-K9-HMTase4; Histone H3 K9 methyltransferase 4; Histone H3-K9 methyltransferase 4; Histone-lysine N-methyltransferase SETDB1; KG1T; KIAA0067; KMT1E; Lysine N-methyltransferase 1E; MGC90670; MKIAA0067; SET domain bifurcated 1; Set domain protein; Bifurcated; 1; SETB1; Setdb1] |
Gene, Accession # | [SETDB1], Gene ID: 9869, NCBI: Q15047.1, UniProt: Q15047 |
Catalog # | MBS2562835 |
Price | $110, $150, $225 |
Order / More Info | SETDB1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |