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Antigenic Specificity | HDAC4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | 1ug/ul |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: HDAC4 (Ab-632) antibody detects endogenous levels of total HDAC4 protein. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. This gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008] |
Immunogen | Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human HDAC4 around the phosphorylation site of serine 632 (A-Q-SP-S-P). |
Other Names | [hdac4; Histone deacetylase], [hdac4] |
Gene, Accession # | [HDAC4], NCBI: AHN52085.1 |
Catalog # | MBS417191 |
Price | $405 |
Order / More Info | HDAC4 Antibody from MYBIOSOURCE INC. |
Product Specific References | Wang AH, et al. (2000) Mol Cell Biol. 20(18): 6904-6912.Grozinger CM, et al. (2000) Proc Natl Acad Sci U S A. 97(14): 7835-7840. |