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Antigenic Specificity | GRK (PAN) |
Clone | [S145-20] |
Host Species | Mouse |
Reactive Species | human, mouse, rat |
Isotype | IgG1 |
Format | APC-Cy7 conjugate |
Size | 0.1 mg |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Detects 70 kDa. Cross-reacts with GRK6. G protein-coupled receptor kinases (GRK) are serine/threonine kinases that phosphorylate a variety of G-protein-coupled receptors (GPCRs), specifically activated forms, including adrenergic receptors, muscarinic acetylcholine receptors, dopamine receptors and opioid receptors. GRK receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. |
Immunogen | Immunogen: Fusion protein amino acids 381-590 (C-terminus) of mouse GRK5. 91% identical to human, and 99% identical to rat. >55% identity with GRK6 and GRK4. >40% identity with GRK7 and RK. |
Other Names | [Mouse Mouse GRK (pan) IgG1; GRK (pan) : APC/Cy7; G protein-coupled receptor kinase; Pan-GRK; GRK-pan; GRK;] |
Gene, Accession # | [GRK], Gene ID: 14773, NCBI: NP_061357.3, UniProt: Q8VEB1 |
Catalog # | MBS8003388 |
Price | $510 |
Order / More Info | GRK (PAN) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |