LIMK1 (Thr-508), phospho-specific [Conserved Site] Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | LIMK1 (Thr-508), phospho-specific [Conserved Site] |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, rat, mouse |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | ELISA, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody was affinity purified using LIMK1 (Thr-508) peptide (without carrier). The antibody detects a 72 kDa* protein corresponding to the molecular mass of LIMK1 on SDS-PAGE immunoblots of activated mouse recombinant LIMK1, but does not detect this protein after lambda phosphatase treatment. LIM kinases (LIMK1 and LIMK2) are serine/threonine kinases that have two zinc finger motifs, known as LIM motifs, in their amino-terminalregulatory domains. LIM kinases are involved in actin cytoskeletal regulation downstream of Rho-family GTPases, PAKs, and ROCK. PAK1 and ROCK phosphorylate LIMK1 or LIMK2 at the conserved Thr-508 or Thr-505 residues in the activation loop, increasing LIMK activity. In addition, VEGF-induced stress fiber formati |
| Immunogen | Immunogen: LIMK1 (Thr-508) synthetic peptide (coupled to carrier protein) corresponding to amino acids surrounding threonine 508 in human LIMK1. This sequence is conserved in rat and mouse LIMK1, and has high homology to Thr-505 in human LIMK2. |
| Other Names | [LIM Kinase 1], [LIMK1; LIMK1; LIMK; LIMK-1; LIMK] |
| Gene, Accession # | Gene ID: 3984, NCBI: NP_002305.1, UniProt: P53667 |
| Catalog # | MBS472033 |
| Price | $385 |
| Order / More Info | LIMK1 (Thr-508), phospho-specific [Conserved Site] Antibody from MYBIOSOURCE INC. |
| Product Specific References | • Okano, I. et al. (1995) J. Biol. Chem. 270:31321.• Edwards, D. C. et al. (1999) Nat. Cell Biol. 1:253.• Kobayashi, M. et al. (2006) EMBOJ 25:713. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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